Lucht Michael, Barnow Sven, Schroeder Winnie, Grabe Hans Joergen, Rosskopf Dieter, Brummer Christian, John Ulrich, Freyberger Harald J, Herrmann Falko H
Department of Psychiatry and Psychotherapy, Hanse-Klinikum Stralsund, Stralsund, Germany.
Neuropsychobiology. 2007;56(1):24-31. doi: 10.1159/000109974. Epub 2007 Oct 17.
Both reduced postsynaptic dopamine D(2) receptor function and the character variable self-directedness (SDD) are related to the level of alcohol consumption. We examined for interactions between DRD2 exon 8(rs6276), a polymorphism which has been associated with various alcohol-related phenotypes, SDD and alcohol consumption.
A total of 144 male and 186 female probands with alcohol dependence or abuse diagnoses and without were included in the study. All subjects were assessed with the alcohol section of the Semi-Structured Assessment for the Genetics of Alcoholism and the Temperament and Character Inventory.
Male probands with A/A genotype reported significantly higher alcohol consumption in a typical week (ANOVA; p = 0.024); those with A/A genotype and low SDD showed particularly high consumption levels (interaction DRD2 x SDD: p = 0.019). Alcohol dependence/abuse (DSM-IV) but not nicotine dependence was also relevant for higher alcohol consumption (trend: p = 0.052). In the female group, only alcohol disorders predicted alcohol consumption.
Our findings support a role for a gene-personality interaction of DRD2 exon 8 x SDD in alcohol consumption in males.
突触后多巴胺D(2)受体功能降低和性格变量自我导向性（SDD）均与酒精摄入量有关。我们研究了与多种酒精相关表型有关的多态性DRD2外显子8（rs6276）、SDD和酒精消费之间的相互作用。
共有144名男性和186名女性先证者纳入研究，他们被诊断为酒精依赖或滥用或无此诊断。所有受试者均接受酒精成瘾遗传学半结构化评估中的酒精部分以及气质和性格量表的评估。
A/A基因型的男性先证者在典型一周内报告的酒精消费量显著更高（方差分析；p = 0.024）；A/A基因型且SDD低的男性先证者显示出特别高的消费水平（DRD2×SDD相互作用：p = 0.019）。酒精依赖/滥用（DSM-IV）而非尼古丁依赖也与较高的酒精消费量相关（趋势：p = 0.052）。在女性组中，只有酒精障碍可预测酒精消费量。
我们的研究结果支持DRD2外显子8×SDD的基因-人格相互作用在男性酒精消费中起作用。
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