关于人类与微生物共生及疾病的生态与进化视角。
An ecological and evolutionary perspective on human-microbe mutualism and disease.
作者信息
Dethlefsen Les, McFall-Ngai Margaret, Relman David A
机构信息
Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA.
出版信息
Nature. 2007 Oct 18;449(7164):811-8. doi: 10.1038/nature06245.
Abstract
The microbial communities of humans are characteristic and complex mixtures of microorganisms that have co-evolved with their human hosts. The species that make up these communities vary between hosts as a result of restricted migration of microorganisms between hosts and strong ecological interactions within hosts, as well as host variability in terms of diet, genotype and colonization history. The shared evolutionary fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease. In this way, looking to ecological and evolutionary principles might provide new strategies for restoring and maintaining human health.
摘要
人类的微生物群落是与人类宿主共同进化的具有独特性和复杂性的微生物混合体。由于微生物在宿主间的迁移受限、宿主体内强烈的生态相互作用，以及宿主在饮食、基因型和定植历史方面的变异性，构成这些群落的物种在不同宿主之间存在差异。人类与其共生细菌的共同进化命运选择了对人类健康至关重要的互利共生相互作用，而破坏这种共同命运的生态或基因变化可能导致疾病。通过这种方式，借鉴生态和进化原理可能会为恢复和维持人类健康提供新策略。
相似文献
1
An ecological and evolutionary perspective on human-microbe mutualism and disease.
Nature. 2007 Oct 18;449(7164):811-8. doi: 10.1038/nature06245.
2
It takes a village: ecological and fitness impacts of multipartite mutualism.
Annu Rev Microbiol. 2013;67:161-78. doi: 10.1146/annurev-micro-092412-155723. Epub 2013 Jun 17.
3
Rethinking "mutualism" in diverse host-symbiont communities.
Bioessays. 2016 Jan;38(1):100-8. doi: 10.1002/bies.201500074. Epub 2015 Nov 16.
4
An out-of-body experience: the extracellular dimension for the transmission of mutualistic bacteria in insects.
Proc Biol Sci. 2015 Apr 7;282(1804):20142957. doi: 10.1098/rspb.2014.2957.
5
Plant evolution driven by interactions with symbiotic and pathogenic microbes.
Science. 2021 Feb 19;371(6531). doi: 10.1126/science.aba6605.
6
Phytophagous insect-microbe mutualisms and adaptive evolutionary diversification.
Evolution. 2008 May;62(5):997-1012. doi: 10.1111/j.1558-5646.2008.00348.x. Epub 2008 Feb 21.
7
Pathogenesis, parasitism and mutualism in the trophic space of microbe-plant interactions.
Trends Microbiol. 2010 Aug;18(8):365-73. doi: 10.1016/j.tim.2010.06.002. Epub 2010 Jul 1.
8
Symbiosis and pathogenesis: evolution of the microbe-host interaction.
Naturwissenschaften. 2000 Jan;87(1):1-11. doi: 10.1007/s001140050001.
9
Origins of symbiosis: shared mechanisms underlying microbial pathogenesis, commensalism and mutualism of plants and animals.
FEMS Microbiol Rev. 2023 Nov 1;47(6). doi: 10.1093/femsre/fuac048.
10
Microbial mutualism promoting the coexistence of competing species: Double-layer model for two competing hosts and one microbial species.
Biosystems. 2022 Jan;211:104589. doi: 10.1016/j.biosystems.2021.104589. Epub 2021 Dec 9.
引用本文的文献
1
A Comprehensive Review of Antibiotic Resistance in the Oral Microbiota: Mechanisms, Drivers, and Emerging Therapeutic Strategies.
Antibiotics (Basel). 2025 Aug 15;14(8):828. doi: 10.3390/antibiotics14080828.
2
Microbiota-gut-brain axis in binge-eating disorder: Towards microbiome-based therapies.
Neurosci Appl. 2024 Aug 29;3:104088. doi: 10.1016/j.nsa.2024.104088. eCollection 2024.
3
Human oral microbiome and its influence on mental health and brain disorders.
AIMS Microbiol. 2025 Apr 14;11(2):242-294. doi: 10.3934/microbiol.2025013. eCollection 2025.
4
The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer.
Front Microbiol. 2025 May 27;16:1591745. doi: 10.3389/fmicb.2025.1591745. eCollection 2025.
5
Dietary microbiota-mediated shifts in gut microbial ecology and pathogen interactions in giant pandas (Ailuropoda melanoleuca).
Commun Biol. 2025 Jun 5;8(1):864. doi: 10.1038/s42003-025-08270-x.
6
Balancing harm and harmony: Evolutionary dynamics between gut microbiota-derived flagellin and TLR5-mediated host immunity and metabolism.
Virulence. 2025 Dec;16(1):2512035. doi: 10.1080/21505594.2025.2512035. Epub 2025 May 30.
7
Engineered Tissue Models to Decode Host-Microbiota Interactions.
Adv Sci (Weinh). 2025 Jun;12(23):e2417687. doi: 10.1002/advs.202417687. Epub 2025 May 14.
8
Gut microbiota and their influence in brain cancer milieu.
J Neuroinflammation. 2025 May 1;22(1):129. doi: 10.1186/s12974-025-03434-2.
9
TCMD: A High-Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio-Based Resources.
Adv Sci (Weinh). 2025 Jul;12(27):e2502156. doi: 10.1002/advs.202502156. Epub 2025 Apr 28.
10
Robust phylogenetic tree-based microbiome association test using repeatedly measured data for composition bias.
BMC Bioinformatics. 2025 Mar 6;26(1):75. doi: 10.1186/s12859-024-06002-2.
本文引用的文献
1
Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers.
FEMS Microbiol Ecol. 2004 Jun 1;48(3):437-46. doi: 10.1016/j.femsec.2004.03.001.
2
Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra.
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13146-51. doi: 10.1073/pnas.0703375104. Epub 2007 Jul 30.
3
Development of the human infant intestinal microbiota.
PLoS Biol. 2007 Jul;5(7):e177. doi: 10.1371/journal.pbio.0050177. Epub 2007 Jun 26.
4
Commensal and pathogenic Escherichia coli use a common pilus adherence factor for epithelial cell colonization.
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10637-42. doi: 10.1073/pnas.0704104104. Epub 2007 Jun 11.
5
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Mol Syst Biol. 2007;3:112. doi: 10.1038/msb4100153. Epub 2007 May 22.
6
Origins of major human infectious diseases.
Nature. 2007 May 17;447(7142):279-83. doi: 10.1038/nature05775.
7
Mutualism and pathogenesis in Xenorhabdus and Photorhabdus: two roads to the same destination.
Mol Microbiol. 2007 Apr;64(2):260-8. doi: 10.1111/j.1365-2958.2007.05671.x.
8
Interactions and competition within the microbial community of the human colon: links between diet and health.
Environ Microbiol. 2007 May;9(5):1101-11. doi: 10.1111/j.1462-2920.2007.01281.x.
9
Virulence is positively selected by transmission success between mammalian hosts.
Curr Biol. 2007 May 1;17(9):783-8. doi: 10.1016/j.cub.2007.03.067. Epub 2007 Apr 19.
10
Local interactions select for lower pathogen infectivity.
Science. 2007 Mar 2;315(5816):1284-6. doi: 10.1126/science.1137126.
Zotero 插件