CD147免疫球蛋白超家族受体的功能及其在病理学中的作用。
CD147 immunoglobulin superfamily receptor function and role in pathology.
作者信息
Iacono Kathryn T, Brown Amy L, Greene Mark I, Saouaf Sandra J
机构信息
University of Pennsylvania, Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th & Hamilton Walk, Philadelphia, PA 19104-6082, USA.
出版信息
Exp Mol Pathol. 2007 Dec;83(3):283-95. doi: 10.1016/j.yexmp.2007.08.014. Epub 2007 Sep 7.
Abstract
The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced.
摘要
免疫球蛋白超家族成员CD147在胎儿、神经元、淋巴细胞和细胞外基质发育中发挥重要作用。在此，我们综述了目前对CD147表达以及与CD147功能及其在包括心脏病、阿尔茨海默病、中风和癌症等病理状况中作用相关的蛋白质相互作用的理解。引入了一个将肿瘤微环境中发现的缺氧状况与CD147表达上调和肿瘤进展联系起来的模型。
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