Bai Yang, Huang Wan, Ma Li-Tian, Jiang Jian-Li, Chen Zhi-Nan
Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
Int J Mol Sci. 2014 Apr 15;15(4):6356-77. doi: 10.3390/ijms15046356.
Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation.
糖蛋白的糖基化是伴随恶性转化的众多分子变化之一。蛋白质的翻译后修饰与肿瘤细胞的黏附、侵袭和转移密切相关。CD147是一种在各种肿瘤细胞表面高度表达的肿瘤相关抗原，是癌症诊断和治疗的潜在靶点。CD147的一个重要生化特性是其高度糖基化。对CD147糖基化结构和功能的研究为癌症靶向治疗的发展提供了有价值的线索。在此，我们综述了目前对CD147糖基化特征以及参与CD147 N-聚糖生物合成的糖基转移酶的认识。最后，我们讨论了调节CD147糖基化的蛋白质以及CD147糖基化的生物学功能。
