具有各向异性可生物降解纳米纤维支架的纤维增强组织工程
Engineering of fiber-reinforced tissues with anisotropic biodegradable nanofibrous scaffolds.
作者信息
Nerurkar Nandan L, Baker Brendon M, Chen Chiu-Yu, Elliott Dawn M, Mauck Robert L
机构信息
Department of Mechanical Engineering, Pennsylvania University, Philadelphia, PA 19104, USA.
出版信息
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:787-90. doi: 10.1109/IEMBS.2006.259395.
The repair of dense fiber-reinforced tissues poses a significant challenge for the tissue engineering community. The function of these structures is largely dependent on their architectural form, and as such, scaffold organization is an important design parameter in generating tissue analogues. To address this issue, we have recently utilized electrospinning to instill controllable fiber anisotropy in nanofibrous scaffolds. This abstract details the mechanical characterization of the bulk and local properties of these scaffolds, and points to their potential application in the repair and/or generation of fiber-reinforced tissues that recapitulate the native form.
致密纤维增强组织的修复对组织工程领域构成了重大挑战。这些结构的功能很大程度上取决于其结构形式，因此，支架组织是生成组织类似物的一个重要设计参数。为了解决这个问题，我们最近利用静电纺丝技术在纳米纤维支架中注入可控的纤维各向异性。本摘要详细介绍了这些支架的整体和局部性能的力学表征，并指出了它们在修复和/或生成重现天然形态的纤维增强组织方面的潜在应用。
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