Burbello A T, Baskovich G A, Dobrokhotova E G, Slesarev V I
Gig Tr Prof Zabol. 1991(8):13-5.
Sodium nitrite induced poisoning resulted into oxidation-reduction disorders with concomitant changes in the ratio of the oxidated and reduced forms towards accumulation of the oxidated equivalents. Antioxidants unithiol, tocopherol acetate, ascorbic acid, methylene blue, violuric acid influenced the oxidation-reduction balance in different ways. The protective action of violuric acid was comparable with that of methylene blue and exceeded the unithiol protective properties. Violuric acid, as compared with unithiol, ascorbic acid and tocopherol, was more effective in decreasing methemoglobin and nitrates contents in blood in methemoglobinemia cases. The violuric acid and methylene blue protective mechanisms are in all probability influenced by the antioxidant properties of these substances and their reductase activity.
亚硝酸钠中毒导致氧化还原紊乱，氧化型与还原型的比例随之改变，致使氧化当量积累。抗氧化剂二巯基丙醇、维生素E醋酸酯、抗坏血酸、亚甲蓝、紫尿酸以不同方式影响氧化还原平衡。紫尿酸的保护作用与亚甲蓝相当，且超过二巯基丙醇的保护性能。与二巯基丙醇、抗坏血酸和维生素E相比，紫尿酸在降低高铁血红蛋白血症患者血液中高铁血红蛋白和硝酸盐含量方面更有效。紫尿酸和亚甲蓝的保护机制很可能受这些物质的抗氧化特性及其还原酶活性影响。
