Philp Deborah, St-Surin Sharleen, Cha Hee-Jae, Moon Hye-Sung, Kleinman Hynda K, Elkin Michael
Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892, USA.
Ann N Y Acad Sci. 2007 Sep;1112:95-103. doi: 10.1196/annals.1415.009.
Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.
胸腺素β4是一种由43个氨基酸组成的小分子，具有多种生物学活性，包括促进细胞迁移、血管生成、细胞存活、蛋白酶产生以及伤口愈合。我们发现在包括转基因胸腺素β4过表达小鼠在内的各种大鼠和小鼠模型中，胸腺素β4可促进毛发生长。我们还通过研究胸腺素β4对毛囊干细胞生长、迁移、分化和蛋白酶产生的影响，确定了其促进毛发生长的作用机制。
