Philp D, Goldstein A L, Kleinman H K
Cell Biology Section, CDBRB, National Institute of Dental and Craniofacial Research (NIDCR), NIH 30/433, Bethesda, MD 20892, USA.
Mech Ageing Dev. 2004 Feb;125(2):113-5. doi: 10.1016/j.mad.2003.11.005.
New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in both normal and aged rodents. It also promotes hair growth in normal and aged rodents. It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair.
新血管形成在许多生理过程中都很重要，包括发育、伤口修复和肿瘤生长。在老龄动物中，血管生成减少，导致伤口愈合不良。我们已经鉴定出一种新型小分子——胸腺素β4，它在正常和老龄啮齿动物中均能促进血管生成和伤口修复。它还能促进正常和老龄啮齿动物的毛发生长。其作用机制是增加血管生成和细胞迁移，目前正处于伤口修复的临床试验阶段。
