Zhan S Y, Lian Z H, Zheng D Z, Gao L
Department of Epidemiology, Beijing Medical University, China.
J Epidemiol Community Health. 1991 Dec;45(4):299-301. doi: 10.1136/jech.45.4.299.
The aim was to examine if there is an effect of fathers' age and of birth order on the occurrence of congenital heart disease.
This was a hospital based case-referent study including use of birth defects surveillance data.
Subjects were 497 cases of congenital heart disease aged between 3 months and 5 years, born in Beijing and Hebei Province, China; 6222 children without congenital heart disease serve as reference baseline.
With stratified analysis and logistic regression analyses, congenital heart disease was found to be associated with fathers' age less than 25 years (odds ratio 2.63), independent of mothers' age and of birth order. There was also evidence to show a higher birth order effect on the occurrence of congenital heart disease independent of parental ages.
Higher birth order and fathers aged less than 25 years were both independently associated with some categories of congenital heart disease and with congenital heart disease overall.
旨在探讨父亲年龄及出生顺序对先天性心脏病发生的影响。
这是一项基于医院的病例对照研究，纳入了出生缺陷监测数据。
研究对象为497例年龄在3个月至5岁之间、在中国北京和河北省出生的先天性心脏病患儿；6222名无先天性心脏病的儿童作为对照基线。
通过分层分析和逻辑回归分析发现，先天性心脏病与父亲年龄小于25岁相关（优势比2.63），且不受母亲年龄和出生顺序的影响。也有证据表明，在不受父母年龄影响的情况下，出生顺序对先天性心脏病的发生有更高的影响。
出生顺序较高以及父亲年龄小于25岁均与某些类型的先天性心脏病以及总体先天性心脏病独立相关。
