Lian Z H, Zack M M, Erickson J D
Am J Hum Genet. 1986 Nov;39(5):648-60.
The association between paternal age and the occurrence of birth defects was studied using data collected in Metropolitan Atlanta. Paternal-age information for babies born with defects was obtained from birth certificates, hospital records, and interviews with mothers; for babies born without defects, the information was obtained from birth certificates. Several statistical techniques were used to evaluate the paternal-age-birth-defects associations for 86 groups of defects. Logistic regression analysis that controlled for maternal age and race indicated that older fathers had a somewhat higher risk for having babies with defects, when all types of defects were combined; an equivalent association for older mothers was not found. Logistic regression analyses also indicated modestly higher risks for older fathers for having babies with ventricular septal defects and atrial septal defects and substantially higher risks for having babies with defects classified in the category chondrodystrophy (largely sporadic achondroplasia) and babies with situs inversus. An association between elevated paternal age and situs inversus has not been reported before; the magnitude of the estimated increased risk for situs inversus was about the same as that found in this study for chondrodystrophy.
利用在大亚特兰大地区收集的数据，研究了父亲年龄与出生缺陷发生之间的关联。患有出生缺陷婴儿的父亲年龄信息来自出生证明、医院记录以及对母亲的访谈；未患出生缺陷婴儿的信息则来自出生证明。运用了几种统计技术来评估86组出生缺陷的父亲年龄与出生缺陷之间的关联。控制了母亲年龄和种族的逻辑回归分析表明，当所有类型的出生缺陷合并计算时，父亲年龄较大的情况下，生出有缺陷婴儿的风险略高；而未发现母亲年龄较大时有类似的关联。逻辑回归分析还表明，父亲年龄较大时生出患有室间隔缺损和房间隔缺损婴儿的风险略有升高，生出患有软骨发育不良（主要是散发性软骨发育不全）类出生缺陷婴儿和内脏反位婴儿的风险大幅升高。之前尚未报道过父亲年龄升高与内脏反位之间的关联；内脏反位估计增加的风险幅度与本研究中软骨发育不良的情况大致相同。
