Reid J L, Bainbridge A D, MacFadyen R J
Department of Medicine and Therapeutics, University of Glasgow, UK.
J Hypertens Suppl. 1991 Dec;9(8):S54-6.
Ambulatory blood pressure recording can provide information on blood pressure changes throughout the day and night and during normal daily activities. The former features are of particular use in evaluating the duration of action and dose-response relationships for new antihypertensive drugs, especially those developed for once daily dosing. Improved precision and multiple measurements through the dose interval may reduce the number of patients required in trials. We have recently used ambulatory blood pressure recording to assess the magnitude and duration of the first dose of an angiotensin converting enzyme (ACE) inhibitor, quinapril, compared to placebo. In addition, the effects on blood pressure of long-acting calcium antagonists, alone and in combination, have been measured. Ambulatory blood pressure recording can complement conventional approaches in determining the dose range, frequency of administration and concentration-effect relationships of new and existing antihypertensive drugs.
动态血压记录可提供有关全天及夜间以及日常正常活动期间血压变化的信息。前一项功能在评估新型抗高血压药物（尤其是那些设计为每日一次给药的药物）的作用持续时间和剂量-反应关系方面特别有用。通过剂量间隔提高测量精度和进行多次测量可能会减少试验所需的患者数量。我们最近使用动态血压记录来评估与安慰剂相比，血管紧张素转换酶（ACE）抑制剂喹那普利首剂的降压幅度和持续时间。此外，还测量了长效钙拮抗剂单独使用及联合使用时对血压的影响。动态血压记录可补充传统方法，用于确定新型和现有抗高血压药物的剂量范围、给药频率及浓度-效应关系。
