Meyer-Sabellek W A
Department of Cardiology, Boehringer Mannheim GmbH, Germany.
J Hypertens Suppl. 1991 Dec;9(8):S60-2.
Different national authorities have different requirements before antihypertensive drugs can be approved for clinical use. Traditionally, antihypertensive treatment is evaluated by blood pressure measurements made by standardized casual readings. Twenty-four-hour ambulatory blood pressure monitoring provides additional information on the antihypertensive profile of a drug. In antihypertensive drug studies, this technique reduces the sample size required, has no placebo effect and provides more detailed information on first-dose effects, the duration of action and dose-response relationships. Accordingly, proposals are being made that might form the basis of European Commission (EC) guidelines for ambulatory blood pressure monitoring, thus standardizing the present different national requirements.
不同国家的管理机构在抗高血压药物获批用于临床使用之前有不同的要求。传统上，抗高血压治疗是通过标准化随机测量的血压来评估的。24小时动态血压监测可提供有关药物抗高血压特征的更多信息。在抗高血压药物研究中，这项技术可减少所需的样本量，没有安慰剂效应，并能提供有关首剂效应、作用持续时间和剂量反应关系的更详细信息。因此，正在提出一些建议，这些建议可能构成欧盟委员会（EC）动态血压监测指南的基础，从而使目前不同国家的要求标准化。
