Kenney Barton, Richkind Kathleen E, Zambrano Eduardo
Yale University School of Medicine, Department of Pathology, New Haven, CT 06520, USA.
Cancer Genet Cytogenet. 2007 Oct 15;178(2):155-9. doi: 10.1016/j.cancergencyto.2007.07.016.
Aneurysmal bone cysts (ABC) are locally destructive bone lesions occurring predominantly in young adults. There has been debate as to the neoplastic nature of these lesions. In recent years, however, compelling evidence of clonal chromosomal abnormalities has indicated a likely neoplastic origin. Although relatively few ABC have been assessed cytogenetically, many of those which have been studied have shown abnormalities of chromosome 17, particularly t(16;17)(q22;p13). We present a case of ABC in a 4-year-old female, which demonstrated the novel translocation t(X;9)(q26;q32).
骨囊肿（ABC）是主要发生于年轻人的具有局部破坏性的骨病变。关于这些病变的肿瘤性质一直存在争议。然而，近年来，克隆性染色体异常的有力证据表明其可能起源于肿瘤。尽管接受细胞遗传学评估的骨囊肿相对较少，但许多已研究的病例显示出17号染色体异常，尤其是t(16;17)(q22;p13)。我们报告一例4岁女性的骨囊肿病例，该病例显示了新的易位t(X;9)(q26;q32)。
