Lin Ying-He, Huang Ping, Lu Xuan, Guan Dong-Hua, Man Yi, Wei Na, Wang Yong-Yue, Gong Ping
Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
J Oral Maxillofac Surg. 2007 Nov;65(11):2340-4. doi: 10.1016/j.joms.2007.06.673.
Early marginal bone loss around dental implants has been found during the bone healing period before stage II surgery despite a lack of apparent cause, and the etiology of this bone loss is unclear. This study was designed to investigate whether interleukin-1 gene polymorphism is associated with the marginal bone loss around the implants before stage II.
One hundred forty-three implants were placed in 59 patients. The patients were divided into 2 groups: 1) test group: with 1 or more marginal bone loss greater than 0.5 mm; and 2) control group: with marginal bone resorption less than 0.5 mm. Polymorphisms of the IL-1alpha and IL-1beta genes (IL-1A-889, IL-1B-511, and IL-1B+3954) were detected by restriction fragment length polymorphism using Ncol, AvaI, and TaqI digestion after polymerase chain reactions.
The frequency of IL-1B-511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (-) group (P < .05). Multiple logistic regressions showed the OR of the II/II versus the I/I+I/II of the IL-1B-511 genotype was 3.933 between the 2 groups. The difference was statistically significant (P < .05). There was no significant difference between the other risk factors.
These results suggest that the IL-1B-511 II/II genotype in individuals is associated with early marginal bone loss around implants.
尽管没有明显原因，但在二期手术前的骨愈合期已发现牙种植体周围早期边缘骨丢失，且这种骨丢失的病因尚不清楚。本研究旨在调查白细胞介素-1基因多态性是否与二期手术前种植体周围的边缘骨丢失有关。
59例患者共植入143颗种植体。患者分为两组：1）试验组：有1处或多处边缘骨丢失大于0.5mm；2）对照组：边缘骨吸收小于0.5mm。聚合酶链反应后，使用Ncol、AvaI和TaqI消化，通过限制性片段长度多态性检测IL-1α和IL-1β基因（IL-1A-889、IL-1B-511和IL-1B+3954）的多态性。
早期边缘骨丢失（+）组患者中IL-1B-511 II/II的频率显著高于早期边缘骨丢失（-）组患者（P<.05）。多因素logistic回归显示，两组间IL-1B-511基因型的II/II与I/I+I/II的比值比为3.933。差异有统计学意义（P<.05）。其他危险因素之间无显著差异。
这些结果表明，个体中的IL-1B-511 II/II基因型与种植体周围早期边缘骨丢失有关。
