D'Abaco Giovanna M, Kaye Andrew H
Department of Surgery, Royal Melbourne Hospital, 5th Floor, Clinical Sciences Building, Parkville, Victoria 3050, Australia.
J Clin Neurosci. 2007 Nov;14(11):1041-8. doi: 10.1016/j.jocn.2007.06.019.
Gliomas, the most common form of brain tumour are characterised by a capacity to invade throughout normal brain tissue. This infiltrative nature is the hallmark of poor prognosis. A greater understanding of the molecular determinants that drive invasion may lead to improved therapy. Integrins are a large family of cell surface receptors that mediate interaction between a cell and the extracellular matrix. Integrins facilitate extracellular matrix dependent organization of the cytoskeleton and activation of intracellular signalling that is required for the regulation of cell adhesion and migration. Since integrins are key regulators of these processes, the role these receptors play in tumour invasion is a field of intense research.
神经胶质瘤是最常见的脑瘤形式，其特征是能够侵入整个正常脑组织。这种浸润性本质是预后不良的标志。对驱动侵袭的分子决定因素有更深入的了解可能会带来更好的治疗方法。整合素是一大类细胞表面受体，介导细胞与细胞外基质之间的相互作用。整合素促进细胞外基质依赖的细胞骨架组织和细胞内信号传导的激活，而这是调节细胞粘附和迁移所必需的。由于整合素是这些过程的关键调节因子，这些受体在肿瘤侵袭中所起的作用是一个深入研究的领域。
