Department of Experimental Medicine-Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University, 00161 Rome, Italy.
J Neuroimmunol. 2010 Jul 27;224(1-2):8-12. doi: 10.1016/j.jneuroim.2010.05.019. Epub 2010 Jun 17.
Increasing pieces of evidence indicate that the chemokine system influences several aspects of brain physiology and pathology. A deregulated chemokine expression pattern is observed during neurological diseases, including multiple sclerosis and brain tumor. Gliomas are the most common primary tumors affecting human central nervous system (CNS). Chemokines expressed by stromal cells or endogenously produced by glioma cells may influence tumor cell migration, invasion, proliferation, angiogenesis and immune cell infiltration in the tumor mass. Herein we focus on chemokines and chemokine receptors expressed by glioma cells and their role in the regulation of glioma cell functional behaviour, including its ability to attract immune cells.
越来越多的证据表明，趋化因子系统会影响大脑生理和病理的多个方面。在包括多发性硬化症和脑肿瘤在内的神经疾病中，观察到趋化因子表达模式失调。神经胶质瘤是影响人类中枢神经系统（CNS）的最常见原发性肿瘤。基质细胞表达的趋化因子或神经胶质瘤细胞内源性产生的趋化因子可能会影响肿瘤细胞在肿瘤中的迁移、侵袭、增殖、血管生成和免疫细胞浸润。本文我们重点介绍神经胶质瘤细胞表达的趋化因子和趋化因子受体及其在调节神经胶质瘤细胞功能行为（包括吸引免疫细胞的能力）中的作用。
