外周血和积液样本中卡波西肉瘤相关疱疹病毒（KSHV）数量与KSHV相关疾病的关系。

Relationship between the quantity of Kaposi sarcoma-associated herpesvirus (KSHV) in peripheral blood and effusion fluid samples and KSHV-associated disease.

作者信息

Marcelin Anne-Geneviève, Motol Jérome, Guihot Amélie, Caumes Eric, Viard Jean-Paul, Dussaix Elisabeth, Cadranel Jacques, Frances Camille, Carcelain Guislaine, Calvez Vincent, Dupin Nicolas

机构信息

Service de Virologie UPRES-EA 2387, Paris, France.

出版信息

J Infect Dis. 2007 Oct 15;196(8):1163-6. doi: 10.1086/521625. Epub 2007 Sep 11.

DOI:10.1086/521625

PMID:17955434

Abstract

The Kaposi sarcoma-associated herpesvirus (KSHV)-DNA level was determined in samples from 71 patients with Kaposi sarcoma (KS), 28 patients with multicentric Castleman disease (MCD), and 8 patients with primary effusion lymphoma (PEL). KSHV-DNA levels were higher in patients with active KS or MCD than in those with KS or MCD in remission. Among patients with active disease, the highest KSHV-DNA levels were observed in effusion fluid samples from patients with PEL (7.2 log(10) copies/150,000 cells), followed by blood samples from patients with MCD and PEL (4.86 and 3.83 log(10) copies/150,000 cells, respectively), and the lowest levels were observed in blood samples from patients with KS (2.63 log(10) copies/150,000 cells). Determining the KSHV-DNA level may be useful in diagnosing KSHV-associated disease and for following up patients with KS when the development of MCD or PEL is suspected.

摘要

在71例卡波西肉瘤（KS）患者、28例多中心Castleman病（MCD）患者和8例原发性渗出性淋巴瘤（PEL）患者的样本中测定了卡波西肉瘤相关疱疹病毒（KSHV）-DNA水平。活动性KS或MCD患者的KSHV-DNA水平高于缓解期的KS或MCD患者。在活动性疾病患者中，PEL患者的渗出液样本中观察到最高的KSHV-DNA水平（7.2 log₁₀拷贝/150,000个细胞），其次是MCD和PEL患者的血液样本（分别为4.86和3.83 log₁₀拷贝/150,000个细胞），而KS患者的血液样本中观察到的水平最低（2.63 log₁₀拷贝/150,000个细胞）。测定KSHV-DNA水平可能有助于诊断KSHV相关疾病，并在怀疑发生MCD或PEL时对KS患者进行随访。