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老年肺癌医疗干预的价值:来自监测、流行病学和最终结果-医疗保险和医疗补助服务中心联邦医院统计(SEER-CMHSF)的结果

The value of medical interventions for lung cancer in the elderly: results from SEER-CMHSF.

作者信息

Woodward Rebecca M, Brown Martin L, Stewart Susan T, Cronin Kathleen A, Cutler David M

机构信息

Harvard Interfaculty Program for Health Systems Improvement, Department of Economics, Harvard University, Cambridge, Massachusetts 02145, USA.

出版信息

Cancer. 2007 Dec 1;110(11):2511-8. doi: 10.1002/cncr.23058.

Abstract

BACKGROUND

Lung cancer is the leading source of cancer mortality and spending. However, the value of spending on the treatment of lung cancer has not been conclusively demonstrated. The authors evaluated the value of medical care between 1983 and 1997 for nonsmall cell lung cancer in the elderly US population.

METHODS

The authors used Surveillance, Epidemiology, and End Results (SEER) data to calculate life expectancy after diagnosis over the period 1983 to 1997. Direct costs for nonsmall cell lung cancer detection and treatment were determined by using Part A and Part B reimbursements from the Continuous Medicare History Sample File (CMHSF) data. The CMHSF and SEER data were linked to calculate lifetime treatment costs over the time period of interest.

RESULTS

Life expectancy improved minimally, with an average increase of approximately 0.60 months. Total lifetime lung cancer spending rose by approximately $20,157 per patient in real, ie, adjusted for inflation, 2000 dollars from the early 1980s to the mid-1990s, for a cost-effectiveness ratio of $403,142 per life year (LY). The cost-effectiveness ratio was $143,614 for localized cancer, $145,861 for regional cancer, and $1,190,322 for metastatic cancer.

CONCLUSIONS

The cost-effectiveness ratio for nonsmall cell lung cancer was higher than traditional thresholds used to define cost-effective care. The most favorable results were for persons diagnosed with early stage cancer. These results suggested caution when encouraging more intensive care for lung cancer patients without first considering the tradeoffs with the costs of this therapy and its potential effects on mortality and/or quality of life.

摘要

背景

肺癌是癌症死亡和支出的主要原因。然而,肺癌治疗支出的价值尚未得到确凿证明。作者评估了1983年至1997年美国老年人群中非小细胞肺癌的医疗价值。

方法

作者使用监测、流行病学和最终结果(SEER)数据来计算1983年至1997年期间诊断后的预期寿命。非小细胞肺癌检测和治疗的直接成本通过使用连续医疗保险历史样本文件(CMHSF)数据中的A部分和B部分报销来确定。将CMHSF和SEER数据链接起来,以计算感兴趣时间段内的终身治疗成本。

结果

预期寿命改善甚微,平均增加约0.60个月。从20世纪80年代初到90年代中期,每位患者的肺癌终身总支出实际增加了约20,157美元(即按2000年通货膨胀调整后的美元),每生命年(LY)的成本效益比为403,142美元。局限性癌症的成本效益比为143,614美元,区域性癌症为145,861美元,转移性癌症为1,190,322美元。

结论

非小细胞肺癌的成本效益比高于用于定义成本效益医疗的传统阈值。最有利的结果是针对诊断为早期癌症的患者。这些结果表明,在鼓励对肺癌患者进行更强化治疗时应谨慎,首先要考虑这种治疗成本及其对死亡率和/或生活质量的潜在影响之间的权衡。

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