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环丙沙星和氧氟沙星对小鼠细胞免疫和体液免疫反应的影响

[The effects of ciprofloxacin and ofloxacin on the cellular and humoral immune response in mice].

作者信息

Usluer G, Ulak G, Erol K, Gürer F, Cingi M I, Ozdemir M, Alpan R S

机构信息

Anadolu Universitesi, Fakültesi Infeksiyon Hastaliklari Anabilim Dali.

出版信息

Mikrobiyol Bul. 1991 Oct;25(4):330-9.

PMID:1795657
Abstract

The effects of a 7 days chemotherapy with ciprofloxacin or ofloxacin on the cellular and humoral immune responses in albino mice were studied. The non-toxic doses of the drugs (10 or 30 mg/kg/day) were used. The delayed-type hypersensitivity reaction to sheep blood cells and skin biopsy were evaluated for cellular immune response. The complement fixation method was applied for the determination of the humoral immune response. Both drugs increased the cellular and humoral immune responses.

摘要

研究了环丙沙星或氧氟沙星进行7天化疗对白化病小鼠细胞免疫和体液免疫反应的影响。使用了无毒剂量的药物(10或30毫克/千克/天)。通过对绵羊血细胞的迟发型超敏反应和皮肤活检来评估细胞免疫反应。采用补体结合法测定体液免疫反应。两种药物均增强了细胞免疫和体液免疫反应。

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