Tawfik A F, Shoeb H A, Bishop S J, al-Shammary F J, Shibl A M
Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
J Chemother. 1990 Oct;2(5):300-5. doi: 10.1080/1120009x.1990.11739033.
Ciprofloxacin, pefloxacin, norfloxacin, and ofloxacin were investigated for immunomodulatory activity on humoral and cell-mediated immune responses. Ciprofloxacin and pefloxacin altered the humoral immune responses of mice to sheep red blood cells. This effect was not exhibited by norfloxacin or ofloxacin. All four quinolones did not alter cell-mediated responses. When these antimicrobial agents were tested for their interaction with human polymorphonuclear phagocytic activity, all agents suppressed this activity. In addition, all except norfloxacin showed anti-inflammatory activity.
研究了环丙沙星、培氟沙星、诺氟沙星和氧氟沙星对体液免疫和细胞介导免疫反应的免疫调节活性。环丙沙星和培氟沙星改变了小鼠对绵羊红细胞的体液免疫反应。诺氟沙星或氧氟沙星未表现出这种效应。所有四种喹诺酮类药物均未改变细胞介导的反应。当测试这些抗菌药物与人多形核吞噬细胞活性的相互作用时，所有药物均抑制了这种活性。此外，除诺氟沙星外，所有药物均显示出抗炎活性。
