Discalzi G, Cioci I, Ganio L, Ponzetti C, Coscia G
Dipartimento di Traumatologia, Ortopedia e Medicina del Lavoro, Università di Torino.
Med Lav. 1991 May-Jun;82(3):248-52.
In order to identify possible relationships between multiple myeloma (MM) and occupational factors, a hospital-based case control type study was carried out on 94 cases of MM and on 188 controls matched for sex, age (S.D. = 2 years) and area of residence, suffering from orthopaedic trauma and free of chronic/degenerative or tumoral diseases. All jobs done for at least a year in a period of 5-30 years before diagnosis were considered. Statistical analysis showed a significant correlation between MM and agricultural work (OR 1.82; I.C. 95% 1.03-3.25), which agrees with the data in the literature. The etiopathogenetic hypotheses reported in the literature are discussed and proposals for further research are made.
为了确定多发性骨髓瘤（MM）与职业因素之间可能存在的关系，对94例MM患者以及188名对照者开展了一项基于医院的病例对照研究。对照者为因骨科创伤就医，无慢性/退行性疾病或肿瘤疾病，且在性别、年龄（标准差=2岁）和居住地区方面与病例匹配。考虑了在诊断前5至30年期间至少从事一年的所有工作。统计分析显示MM与农业工作之间存在显著相关性（比值比1.82；95%置信区间1.03 - 3.25），这与文献数据相符。文中讨论了文献中报道的病因发病机制假说，并提出了进一步研究的建议。
