染色体乘客复合体：一为全体，全体为一。

The chromosomal passenger complex: one for all and all for one.

作者信息

Ruchaud Sandrine, Carmena Mar, Earnshaw William C

机构信息

Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.

出版信息

Cell. 2007 Oct 19;131(2):230-1. doi: 10.1016/j.cell.2007.10.002.

DOI:10.1016/j.cell.2007.10.002

PMID:17956723

Abstract

The chromosomal passenger complex-composed of Aurora B kinase and its regulatory subunits INCENP, Survivin, and Borealin-modulates multiple events during mitosis. In this issue, Jeyaprakash et al. (2007) report the crystal structure of the regulatory subunit complex and reveal how interactions between these proteins promote the targeting and function of the chromosomal passenger complex during mitosis.

摘要

由极光激酶B及其调节亚基INCENP、生存素和博瑞林组成的染色体乘客复合体在有丝分裂过程中调节多个事件。在本期中，杰亚普拉卡什等人（2007年）报道了调节亚基复合体的晶体结构，并揭示了这些蛋白质之间的相互作用如何在有丝分裂过程中促进染色体乘客复合体的靶向定位和功能。