染色体乘客复合物（CPC）：从易手到有丝分裂的教父。
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
机构信息
Wellcome Trust Centre for Cell Biology, University of Edinburgh, ICB Michael Swann Building, King's Buildings Mayfield Road, Edinburgh EH9 3JR Scotland, UK.
出版信息
Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474.
Abstract
Successful cell division requires the precise and timely coordination of chromosomal, cytoskeletal and membrane trafficking events. These processes are regulated by the competing actions of protein kinases and phosphatases. Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC). This complex targets to different locations at differing times during mitosis, where it regulates key mitotic events: correction of chromosome-microtubule attachment errors; activation of the spindle assembly checkpoint; and construction and regulation of the contractile apparatus that drives cytokinesis. Our growing understanding of the CPC has seen it develop from a mere passenger riding on the chromosomes to one of the main controllers of mitosis.
摘要
成功的细胞分裂需要精确和及时地协调染色体、细胞骨架和膜运输事件。这些过程受蛋白激酶和磷酸酶的竞争作用调节。Aurora B 是研究最深入的激酶之一。它与着丝粒内蛋白（INCENP）、Borealin（也称为 Dasra）和Survivin 一起形成染色体乘客复合物（CPC）。该复合物在有丝分裂的不同时间靶向不同的位置，在那里它调节关键的有丝分裂事件：纠正染色体-微管附着错误；激活纺锤体组装检查点；以及构建和调节驱动胞质分裂的收缩装置。我们对 CPC 的认识不断加深，它已经从一个仅仅在染色体上搭乘的乘客发展成为有丝分裂的主要控制器之一。
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