Ramachandran J, Farmer S W, Liles S, Li C H
Biochim Biophys Acta. 1976 Apr 23;428(2):347-54. doi: 10.1016/0304-4165(76)90042-8.
The ability of alpha-melanotropin and a series of synthetic peptides related to adrenocorticotropin (ACTH) to stimulate steroidogenesis in isolated rat adrenal cells, melanin dispersion in frog melanophores and lipolysis in rat and rabbit fat cells have been studied. It was found that the steroidogenic activity closely paralleled the lipolytic activity of these peptides in rat fat cells, whereas the melanocyte stimulating activity paralleled the lipolytic activity in rabbit fat cells. These results indicate that the structural requirements for stimulating steroidogenesis in isolated rat adrenal cells and lipolysis in isolated rat fat cells are quite similar. The structural features required for eliciting lipolysis in rabbit fat cells appear to be very similar to those necessary for stimulating frog melanophores. The possibility that regulation of lipid metabolism in the rabbit may be a new function acquired by melanotropin is discussed.
已对α-促黑素以及一系列与促肾上腺皮质激素（ACTH）相关的合成肽在分离的大鼠肾上腺细胞中刺激类固醇生成、在青蛙黑素细胞中诱导黑色素分散以及在大鼠和兔子脂肪细胞中促进脂肪分解的能力进行了研究。结果发现，这些肽在大鼠脂肪细胞中的类固醇生成活性与脂肪分解活性密切平行，而在兔子脂肪细胞中，促黑素细胞活性与脂肪分解活性平行。这些结果表明，在分离的大鼠肾上腺细胞中刺激类固醇生成和在分离的大鼠脂肪细胞中促进脂肪分解的结构要求非常相似。在兔子脂肪细胞中引发脂肪分解所需的结构特征似乎与刺激青蛙黑素细胞所需的特征非常相似。本文还讨论了促黑素可能获得调节兔子脂质代谢这一新功能的可能性。
