Reed Julie E, Arnal Anna Arola, Neidle Stephen, Vilar Ramón
Department of Chemistry, Imperial College London, South Kensington, UK.
J Am Chem Soc. 2006 May 10;128(18):5992-3. doi: 10.1021/ja058509n.
Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.
已制备出两种新型烷基胺取代的镍（II）-双水杨醛缩邻苯二胺配合物，并研究了它们与DNA的相互作用。荧光共振能量转移研究表明，这些配合物具有显著稳定G-四链体DNA的能力。此外，端粒重复扩增/ Taq酶分析表明，这些配合物在低微摩尔浓度下能抑制端粒酶。
