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伏隔核内注射苯丙胺诱发的转圈行为。

Circling induced by intra-accumbens amphetamine injections.

作者信息

Colle L M, Wise R A

机构信息

Department of Psychology, Concordia University, Montreal, Quebec, Canada.

出版信息

Psychopharmacology (Berl). 1991;105(2):157-61. doi: 10.1007/BF02244302.

Abstract

Microinjections of d-amphetamine (5.0, 10.0 and 20.0 micrograms/0.5 microliters) into the nucleus accumbens caused reliable dose-dependent circling away from the side of injection. Injections of l-amphetamine were not effective, ruling out non-specific effects of pH, osmolarity and the like and also ruling out noradrenergic actions as explanations of the behavioral effects. Injections of d-amphetamine into the ventral caudate were less potent than those into the nucleus accumbens, suggesting nucleus accumbens rather than more dorsal tissue as the site of this behavioral effect. These data suggest that asymmetrical activation of the nucleus accumbens is a sufficient condition to induce circling behavior and raise questions for the commonly accepted view that asymmetrical activation of the caudate is a necessary condition for dopamine dependent circling behavior.

摘要

向伏隔核微量注射右旋苯丙胺(5.0、10.0和20.0微克/0.5微升)会导致可靠的剂量依赖性绕圈行为,动物会从注射侧转身离开。注射左旋苯丙胺则没有效果,这排除了pH值、渗透压等非特异性效应,也排除了去甲肾上腺素能作用作为行为效应的解释。向腹侧尾状核注射右旋苯丙胺的效力低于向伏隔核注射,这表明伏隔核而非更靠背侧的组织是这种行为效应的发生部位。这些数据表明,伏隔核的不对称激活是诱导绕圈行为的充分条件,并对尾状核的不对称激活是多巴胺依赖性绕圈行为的必要条件这一普遍接受的观点提出了质疑。

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