Joyce J N, Van Hartesveldt C
Pharmacol Biochem Behav. 1984 Apr;20(4):551-7. doi: 10.1016/0091-3057(84)90304-6.
Unilateral intrastriatal injections of dopamine (DA; 25 micrograms/0.25 microliters) or amphetamine ( AMPHET ; 25 micrograms/0.25 microliters) induced contralateral postural deviation and contralateral rotation that varied systematically across the estrous cycle of Long-Evans hooded rats. Both the deviation and rotation elicited by either drug were suppressed during the early part of the day of proestrus (2-6 hours after lights on) and were enhanced on the day of estrus, compared to the other days of the estrous cycle. However, when the behaviors elicited by the two drugs were examined across the day of proestrus, it was found that postural deviation and rotation changed independently. Postural deviation elicited by intrastriatal DA and AMPHET was suppressed on the day of proestrus at 4 and 7 hours after lights on, but was enhanced to the level seen during estrus at 11 hours after lights on. In contrast, contralateral rotation induced by either drug was suppressed 4, 7 and 11 hours after lights on and was enhanced only by the morning of estrus. These data suggest that there are separate DA-modulated mechanisms within the striatum for postural deviation and contralateral rotation, and that these mechanisms are differentially affected across the estrous cycle.
对长-伊文斯有帽大鼠单侧纹状体内注射多巴胺（DA；25微克/0.25微升）或苯丙胺（AMPHET；25微克/0.25微升）会诱发对侧姿势偏差和对侧旋转，且这些反应在动情周期中呈现出系统性变化。与动情周期的其他日子相比，两种药物诱发的偏差和旋转在动情前期当天的早些时候（开灯后2 - 6小时）受到抑制，而在发情当天增强。然而，当在动情前期全天检查两种药物诱发的行为时，发现姿势偏差和旋转是独立变化的。纹状体内注射DA和AMPHET诱发的姿势偏差在动情前期当天开灯后4小时和7小时受到抑制，但在开灯后11小时增强至发情期所见水平。相比之下，两种药物诱发的对侧旋转在开灯后4小时、7小时和11小时受到抑制，仅在发情期早晨增强。这些数据表明，纹状体内存在分别由DA调节的姿势偏差和对侧旋转机制，并且这些机制在动情周期中受到不同影响。
