Joyce J N, Davis R E, Van Hartesveldt C
Eur J Pharmacol. 1981 Jun 10;72(1):1-10. doi: 10.1016/0014-2999(81)90290-9.
Dopamine or its vehicle saline was injected unilaterally into dorsal striatum, ventral striatum, or sites outside the striatum in adult male rats. Direction, duration and frequencies of ongoing behaviors were measured. Dopamine injected into any site within the striatum immediately elicited more contralaterally directed behavior than the vehicle injected into the same site. The contralaterally directed behaviors were no longer duration when injected into the dorsal than into the ventral striatum, a result which might reflect regional differences in numbers of dopamine receptors or distribution of efferents. At the doses employed (25 and 100 microgram), dopamine injected unilaterally into the striatum did not induce rotation, stereotyped behavior, or even a significant change in the frequencies of ongoing behaviors; rather, all ongoing behaviors were expressed in a contralateral direction. Thus, the behavioral effects of dopamine in the striatum are best understood as a change in sensory-motor responsiveness.
将多巴胺或其溶媒生理盐水单侧注射到成年雄性大鼠的背侧纹状体、腹侧纹状体或纹状体以外的部位。测量持续行为的方向、持续时间和频率。注射到纹状体内任何部位的多巴胺比注射到相同部位的溶媒立即引发更多的对侧定向行为。与注射到腹侧纹状体相比，注射到背侧纹状体时对侧定向行为的持续时间不再延长，这一结果可能反映了多巴胺受体数量或传出纤维分布的区域差异。在所使用的剂量（25微克和100微克）下，单侧注射到纹状体的多巴胺不会诱导旋转、刻板行为，甚至不会引起持续行为频率的显著变化；相反，所有持续行为都以对侧方向表现出来。因此，纹状体内多巴胺的行为效应最好理解为感觉运动反应性的变化。
