细菌基因组测序及其在传染病中的应用。

Bacterial genome sequencing and its use in infectious diseases.

作者信息

Fournier Pierre-Edouard, Drancourt Michel, Raoult Didier

机构信息

Rickettsies Unit, Faculty of Medicine, University of the Mediterranean, Marseille, France.

出版信息

Lancet Infect Dis. 2007 Nov;7(11):711-23. doi: 10.1016/S1473-3099(07)70260-8.

DOI:10.1016/S1473-3099(07)70260-8

PMID:17961857

Abstract

The availability of genome sequences is revolutionising the fields of bacteriology and infectious diseases. By mid-2007, 479 bacterial genomes from 352 distinct species have been sequenced, including representatives of all notable human pathogens. Additionally, the genomes of several strains from each of 55 species have been sequenced. This tremendous amount of genomic data has led to unprecedented advances in pathogen diagnosis, genotyping, detection of virulence, and detection of resistance to antibiotics. We review current achievements in these fields and potential developments in the future for the clinical microbiology laboratory.

摘要

基因组序列的可得性正在彻底改变细菌学和传染病领域。到2007年年中，已对来自352个不同物种的479个细菌基因组进行了测序，其中包括所有重要人类病原体的代表。此外，还对55个物种中每个物种的多个菌株的基因组进行了测序。这大量的基因组数据已在病原体诊断、基因分型、毒力检测和抗生素耐药性检测方面带来了前所未有的进展。我们综述了这些领域的当前成就以及临床微生物学实验室未来的潜在发展。