用于新型隐形眼镜基眼用药物递送系统的聚合物水凝胶：综述
Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: a review.
作者信息
Xinming Li, Yingde Cui, Lloyd Andrew W, Mikhalovsky Sergey V, Sandeman Susan R, Howel Carol A, Liewen Liao
机构信息
Department of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Technology, No. 24 Dongsha Street, Fangzhi Road, Haizhu District, Guangzhou 510225, Guangdong, PR China.
出版信息
Cont Lens Anterior Eye. 2008 Apr;31(2):57-64. doi: 10.1016/j.clae.2007.09.002. Epub 2007 Oct 25.
Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye drops account for more than 90% of all ophthalmic formulations. The bioavailability of ophthalmic drugs can be improved by a soft contact lens-based ophthalmic drug delivery system. Several polymeric hydrogels have been investigated for soft contact lens-based ophthalmic drug delivery systems: (i) polymeric hydrogels for conventional contact lens to absorb and release ophthalmic drugs; (ii) polymeric hydrogels for piggyback contact lens combining with a drug plate or drug solution; (iii) surface-modified polymeric hydrogels to immobilize drugs on the surface of contact lenses; (iv) polymeric hydrogels for inclusion of drugs in a colloidal structure dispersed in the lens; (v) ion ligand-containing polymeric hydrogels; (vi) molecularly imprinted polymeric hydrogels which provide the contact lens with a high affinity and selectivity for a given drug. Polymeric hydrogels for these contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.
通过滴眼液给药的药物仅有约5%具有生物利用度，而目前滴眼液占所有眼科制剂的90%以上。基于软性隐形眼镜的眼科药物递送系统可提高眼科药物的生物利用度。已对几种用于基于软性隐形眼镜的眼科药物递送系统的聚合物水凝胶进行了研究：(i)用于传统隐形眼镜以吸收和释放眼科药物的聚合物水凝胶；(ii)用于背负式隐形眼镜并与药板或药液结合的聚合物水凝胶；(iii)用于将药物固定在隐形眼镜表面的表面改性聚合物水凝胶；(iv)用于将药物包含在分散于镜片中的胶体结构中的聚合物水凝胶；(v)含离子配体的聚合物水凝胶；(vi)分子印迹聚合物水凝胶，其使隐形眼镜对给定药物具有高亲和力和选择性。本文综述对用于这些基于隐形眼镜的眼科药物递送系统的聚合物水凝胶、它们的优缺点进行了批判性分析。
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