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使用三维气泡堆积法进行冷冻手术规划。

Cryosurgery planning using bubble packing in 3D.

作者信息

Tanaka Daigo, Shimada Kenji, Rossi Michael R, Rabin Yoed

机构信息

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.

出版信息

Comput Methods Biomech Biomed Engin. 2008 Apr;11(2):113-21. doi: 10.1080/10255840701336653.

Abstract

As part of an ongoing project to develop automated tools for cryosurgery planning, the current study focuses on the development of a 3D bubble packing method. A proof-of-concept for the new method is demonstrated on five prostate models, reconstructed from ultrasound images. The new method is a modification of an established method in 2D. Ellipsoidal bubbles are packed in the volume of the prostate in the current study; such bubbles can be viewed as a first-order approximation of a frozen region around a single cryoprobe. When all cryoprobes are inserted to the same depth, optimum planning was found to occur at about 60% of the length of the prostate (measured from its apex), which leads to cooling of approximately 75% of the prostate volume below a specific temperature threshold of - 22 degrees C. Bubble packing has the potential to dramatically reduce the run time for automated planning.

摘要

作为正在进行的开发冷冻手术规划自动化工具项目的一部分,当前研究聚焦于一种三维气泡填充方法的开发。在从超声图像重建的五个前列腺模型上展示了该新方法的概念验证。新方法是对二维既定方法的一种改进。在当前研究中,椭球形气泡被填充于前列腺体积内;此类气泡可被视为单个冷冻探针周围冷冻区域的一阶近似。当所有冷冻探针插入到相同深度时,发现最佳规划出现在前列腺长度的约60%处(从其顶端测量),这会使约75%的前列腺体积冷却至低于-22摄氏度的特定温度阈值。气泡填充有潜力大幅减少自动化规划的运行时间。

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本文引用的文献

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A semi-empirical treatment planning model for optimization of multiprobe cryosurgery.
Phys Med Biol. 2000 May;45(5):1085-98. doi: 10.1088/0031-9155/45/5/301.
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Mechanisms of tissue injury in cryosurgery.冷冻手术中组织损伤的机制。
Cryobiology. 1998 Nov;37(3):171-86. doi: 10.1006/cryo.1998.2115.

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