通过磁共振成像(MRI)对人类产前发育进行可视化。

Visualization of human prenatal development by magnetic resonance imaging (MRI).

作者信息

Shiota Kohei, Yamada Shigehito, Nakatsu-Komatsu Tomoko, Uwabe Chigako, Kose Katsumi, Matsuda Yoshimasa, Haishi Tomoyuki, Mizuta Shinobu, Matsuda Tetsuya

机构信息

Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

出版信息

Am J Med Genet A. 2007 Dec 15;143A(24):3121-6. doi: 10.1002/ajmg.a.31994.

Abstract

It is essential to visualize the structures of embryos and their internal organs three-dimensionally to analyze morphogenesis; this used to rely solely on serial histological sectioning and solid reconstruction, which were tedious and time-consuming. We have applied imaging with a magnetic resonance (MR) microscope equipped with a 2.35 T superconducting magnet to visualize human embryos; we were successful in acquiring high-resolution sectional images and in identifying the detailed structures of major organs. The imaging process was facilitated by using a super-parallel MR microscope. A dataset of MR images of more than 1,000 human embryos, now collected, will be important for future biomedical research and for education.

摘要

为了分析形态发生过程,对胚胎及其内部器官的结构进行三维可视化至关重要;过去这完全依赖于连续组织切片和实体重建,既繁琐又耗时。我们应用了配备2.35 T超导磁体的磁共振(MR)显微镜进行成像,以可视化人类胚胎;我们成功获取了高分辨率的断层图像,并识别出主要器官的详细结构。使用超并行MR显微镜简化了成像过程。现已收集的1000多个人类胚胎的MR图像数据集,对未来的生物医学研究和教育将具有重要意义。

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