Matsuda Yoshimasa, Utsuzawa Shin, Kurimoto Takeaki, Haishi Tomoyuki, Yamazaki Yukako, Kose Katsumi, Anno Izumi, Marutani Mitsuhiro
Institute of Applied Physics, University of Tsukuba, Tsukuba, Japan.
Magn Reson Med. 2003 Jul;50(1):183-9. doi: 10.1002/mrm.10515.
A super-parallel MR microscope in which multiple (up to 100) samples can be imaged simultaneously at high spatial resolution is described. The system consists of a multichannel transmitter-receiver system and a gradient probe array housed in a large-bore magnet. An eight-channel MR microscope was constructed for verification of the system concept, and a four-channel MR microscope was constructed for a practical application. Eight chemically fixed mouse fetuses were simultaneously imaged at the 200 micro m(3) voxel resolution in a 1.5 T superconducting magnet of a whole-body MRI, and four chemically fixed human embryos were simultaneously imaged at 120 micro m(3) voxel resolution in a 2.35 T superconducting magnet. Although the spatial resolutions achieved were not strictly those of MR microscopy, the system design proposed here can be used to attain a much higher spatial resolution imaging of multiple samples, because higher magnetic field gradients can be generated at multiple positions in a homogeneous magnetic field.
本文描述了一种超并行磁共振显微镜，它能够在高空间分辨率下同时对多个（多达100个）样本进行成像。该系统由一个多通道发射 - 接收系统和一个置于大孔径磁体中的梯度探头阵列组成。为验证系统概念构建了一个八通道磁共振显微镜，为实际应用构建了一个四通道磁共振显微镜。在全身MRI的1.5T超导磁体中，以200μm³体素分辨率同时对八个化学固定的小鼠胎儿进行成像；在2.35T超导磁体中，以120μm³体素分辨率同时对四个化学固定的人类胚胎进行成像。尽管所实现的空间分辨率并非严格意义上的磁共振显微镜分辨率，但此处提出的系统设计可用于实现多个样本的更高空间分辨率成像，因为在均匀磁场中的多个位置可以产生更高的磁场梯度。
