在开始服用口服避孕药时处于产后状态的墨西哥裔美国女性队列中，胆囊切除术的高发生率。
A high cholecystectomy rate in a cohort of Mexican American women who are postpartum at the time of oral contraceptive pill initiation.
作者信息
Stuart Gretchen S, Tang Jennifer H, Heartwell Stephen F, Westhoff Carolyn L
机构信息
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7030, USA.
出版信息
Contraception. 2007 Nov;76(5):357-9. doi: 10.1016/j.contraception.2007.06.016.
BACKGROUND
Opinions regarding the association between gallbladder disease and oral contraceptive (OCs) differ. The objective of this article is to quantify cholecystectomy rate among women initiating OCs.
STUDY DESIGN
Women under the age of 25 years were enrolled at four sites in a randomized trial evaluating initiation of OCs. Hospitalizations while enrolled were elicited during follow-up interviews, and medical records of women who underwent cholecystectomy were reviewed.
RESULTS
Of 757 women enrolled at University of Texas Southwestern Medical Center (UTSW), 8 underwent cholecystectomy, a rate of 25.3/1000 woman-years (95% CI=8.1, 42.5). All eight were Mexican American and postpartum when they initiated OCs. The expected rate is 4.2/1000 woman-years for U.S. women aged 15-44.
CONCLUSIONS
Women enrolled at the UTSW site had an increased rate of cholecystectomy and were more likely to be postpartum and Mexican American than women enrolled at the other sites.
背景
关于胆囊疾病与口服避孕药（OCs）之间关联的观点存在差异。本文的目的是量化开始使用OCs的女性中的胆囊切除术发生率。
研究设计
25岁以下的女性在四个地点参加了一项评估OCs起始使用情况的随机试验。在随访访谈中收集入组期间的住院情况，并查阅接受胆囊切除术女性的病历。
结果
在德克萨斯大学西南医学中心（UTSW）入组的757名女性中，有8人接受了胆囊切除术，发生率为25.3/1000人年（95%置信区间=8.1，42.5）。所有8人都是墨西哥裔美国人，开始使用OCs时处于产后状态。美国15 - 44岁女性的预期发生率为4.2/1000人年。
结论
与其他地点入组的女性相比，UTSW地点入组的女性胆囊切除术发生率更高，且更可能处于产后状态和为墨西哥裔美国人。
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