人类体内的大多数淋巴细胞真的存在于肠道中吗？

Do most lymphocytes in humans really reside in the gut?

作者信息

Ganusov Vitaly V, De Boer Rob J

机构信息

Theoretical Biology, Utrecht University, Utrecht, The Netherlands.

出版信息

Trends Immunol. 2007 Dec;28(12):514-8. doi: 10.1016/j.it.2007.08.009. Epub 2007 Oct 26.

DOI:10.1016/j.it.2007.08.009

PMID:17964854

Abstract

It is widely believed that the gut, and particularly the lamina propria (LP) of the gut, contains most of the lymphocytes in humans. The strong depletion of CD4(+) T cells from the gut LP of HIV-infected patients was, therefore, suggested to be such a large, irreversible insult that it could explain HIV disease progression. However, reviewing data from different mammalian species, we found that only 5%-20% of all lymphocytes reside in the gut, and that only 1%-9% of the total lymphocyte number is located in the gut LP. Our findings suggest that spleen and lymph nodes, rather than the gut, are the largest immune compartments in mammals.

摘要

人们普遍认为，肠道，尤其是肠道固有层（LP），包含了人类体内大部分淋巴细胞。因此，有人提出，HIV感染患者肠道LP中CD4(+) T细胞的大量耗竭是一种如此巨大、不可逆的损伤，以至于可以解释HIV疾病的进展。然而，在回顾来自不同哺乳动物物种的数据时，我们发现，所有淋巴细胞中只有5%-20%存在于肠道中，并且肠道LP中的淋巴细胞数量仅占淋巴细胞总数的1%-9%。我们的研究结果表明，在哺乳动物中，脾脏和淋巴结而非肠道才是最大的免疫区室。