放射性碘治疗在低分化甲状腺癌中的应用
Radioactive iodine therapy in poorly differentiated thyroid cancer.
作者信息
Tuttle R Michael, Grewal Ravinder K, Larson Steve M
机构信息
Department of Radiology, Memorial Hospital, Weill Medical College of Cornell University New York, NY, USA.
出版信息
Nat Clin Pract Oncol. 2007 Nov;4(11):665-8. doi: 10.1038/ncponc0979.
BACKGROUND
A 55-year-old male was diagnosed with poorly differentiated thyroid cancer after total thyroidectomy, which was performed because of progressive enlargement of a dominant thyroid nodule. He developed an early cervical recurrence that was treated with modified neck dissection. He subsequently developed biopsy-proven progressive pulmonary metastases.
INVESTIGATIONS
Neck and chest CT scans, laboratory tests, CT-guided fine-needle aspiration biopsy, [18F]-2-fluoro-2-deoxy-D-glucose-PET scan, lesional dosimetry using 124I PET scan, diagnostic radioactive iodine (RAI) scanning, whole-body and blood RAI dosimetry, and single-photon-emission CT.
DIAGNOSIS
Stage IV poorly differentiated thyroid cancer.
MANAGEMENT
Surgical resection of cervical recurrence, RAI therapy.
背景
一名55岁男性因甲状腺优势结节逐渐增大接受了全甲状腺切除术，术后被诊断为低分化甲状腺癌。他出现了早期颈部复发，接受了改良颈部清扫术治疗。随后，他经活检证实出现了进行性肺转移。
检查
颈部和胸部CT扫描、实验室检查、CT引导下细针穿刺活检、[18F]-2-氟-2-脱氧-D-葡萄糖-PET扫描、使用124I PET扫描进行病灶剂量测定、诊断性放射性碘（RAI）扫描、全身和血液RAI剂量测定以及单光子发射CT。
诊断
IV期低分化甲状腺癌。
治疗
手术切除颈部复发病灶，放射性碘治疗。
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