抗中性粒细胞胞浆抗体相关性血管炎患者血清白细胞介素-18浓度上调。
Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis.
作者信息
Hultgren O, Andersson B, Hahn-Zoric M, Almroth G
机构信息
Department of Clinical Immunology, Sahlgren's University Hospital, Göteborg, Sweden.
出版信息
Autoimmunity. 2007 Nov;40(7):529-31. doi: 10.1080/08916930701622783.
We investigated circulating interleukin-18 concentrations in patients with ANCA-associated vasculitis (ASV) and healthy control subjects, and included a group of hemodialysis patients, a patient group previously reported to show high IL-18 plasma levels. Anti-proteinase 3 (PR3) and anti-myeloperoxidase (MPO) serum levels were also measured. Interestingly we found significantly increased serum IL-18 concentrations in ASV patients as compared to healthy controls, 437 vs. 185 pg/ml (p < 0.0001). The increase of IL-18 production was similar irrespective of presence of autoantibodies to PR3 or MPO. As expected the hemodialysis patients also showed significantly increased circulating IL-18 concentrations as compared to control subjects.
我们研究了抗中性粒细胞胞浆抗体相关性血管炎（ASV）患者和健康对照者循环白细胞介素-18（IL-18）的浓度，并纳入了一组血液透析患者，该组患者先前报道显示血浆IL-18水平较高。还检测了抗蛋白酶3（PR3）和抗髓过氧化物酶（MPO）血清水平。有趣的是，我们发现与健康对照相比，ASV患者血清IL-18浓度显著升高，分别为437 pg/ml和185 pg/ml（p<0.0001）。无论是否存在针对PR3或MPO的自身抗体，IL-18产生的增加情况相似。正如预期的那样，与对照受试者相比，血液透析患者的循环IL-18浓度也显著升高。
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