Carmona-Sánchez Ramón, Esmer-Sánchez David, Tostado-Fernández Fernando Alvarez
Servicio de Gastroenterología y Departamento de Medicina Interna, Hospital Angeles-Centro Médico del Potosí. San Luis Potosí, México.
Rev Gastroenterol Mex. 2007 Apr-Jun;72(2):100-3.
The esophageal manometry (EM) is an invasive procedure that causes nasal pain, pharyngeal pain, and nausea. A topical anesthetic may improve tolerance of the examination.
To compare the effectiveness of 10% lidocaine with 20% benzocaine as topical anesthetics in order to reduce discomfort during an EM.
251 patients who had been prescribed an EM received either lidocaine or benzocaine in the nose and pharynx before inserting the catheter An EM was carried out using the usual pull-trough technique and an observer registered the insertion time of the catheter. Patients assessed the intensity of nasal pain and nausea by means of a visual analog scale. Finally, patients were asked whether, if necessary, they would repeat the study.
127 patients were studied in the lidocaine group and 124 in the benzocaine group. The EM was carried out on all patients without complications. Although benzocaine tended to be the preferred anesthetic, no significant differences were found between the groups in relation to nasal pain, nausea, and insertion time. The percentage of patients with moderate or intense discomfort was significantly less in the benzocaine group (nasal pain 10 vs. 33%, p < 0.001; and nausea 24 vs. 36%, p = 0.05). A similar percentage of patients said they would not agree to having another EM (p = NS).
Both lidocaine and benzocaine are topical anesthetics that can reduce discomfort during an EM. Benzocaine seems to achieve a better effect among more patients submitted to this procedure.
食管测压法(EM)是一种侵入性操作,会引起鼻痛、咽痛和恶心。局部麻醉剂可能会提高对该检查的耐受性。
比较10%利多卡因和20%苯佐卡因作为局部麻醉剂在减少食管测压法检查期间不适方面的有效性。
251名被开具食管测压法检查的患者在插入导管前在鼻腔和咽部接受了利多卡因或苯佐卡因。使用常规的牵拉技术进行食管测压法检查,一名观察者记录导管的插入时间。患者通过视觉模拟量表评估鼻痛和恶心的强度。最后,询问患者如有必要是否会重复该检查。
利多卡因组研究了127名患者,苯佐卡因组研究了124名患者。所有患者均顺利进行了食管测压法检查,无并发症。虽然苯佐卡因似乎是更受青睐的麻醉剂,但两组在鼻痛、恶心和插入时间方面未发现显著差异。苯佐卡因组中中度或重度不适患者的百分比显著更低(鼻痛:10%对33%,p<0.001;恶心:24%对36%,p=0.05)。表示不同意再次进行食管测压法检查的患者比例相似(p=无显著差异)。
利多卡因和苯佐卡因都是可以减少食管测压法检查期间不适的局部麻醉剂。在接受该检查的更多患者中,苯佐卡因似乎能取得更好的效果。