用于消化不良的胃肠鸡尾酒中粘性利多卡因与苯佐卡因的前瞻性随机研究。
Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia.
作者信息
Vilke Gary M, Jin Albert, Davis Daniel P, Chan Theodore C
机构信息
Department of Emergency Medicine, University of California-San Diego Medical Center, 200 West Arbor Drive, Mailcode #8676, San Diego, CA 92103, USA.
出版信息
J Emerg Med. 2004 Jul;27(1):7-9. doi: 10.1016/j.jemermed.2003.12.026.
We hypothesized that Benzocaine (Hurricaine) would work as quickly and effectively as viscous Lidocaine in this preparation. This was a prospective randomized, single-blinded comparison between Benzocaine and Lidocaine as the topical anesthetic in a gastrointestinal (GI) cocktail. Patients 18 years or older were approached for participation when a GI cocktail was ordered by the Emergency Physician. Patients were randomized to equivalent doses of either Benzocaine or viscous Lidocaine in addition to 30 cc of Maalox and 10 cc of Donnatal. Assessment using a visual analog pain scale occurred at time intervals of 0, 5, 15, and 30 min. Eighty-two patients were enrolled (44 to Benzocaine, 38 to viscous Lidocaine), with each group having a statistically significant improvement in pain (p < 0.001). There were no statistical differences between the Benzocaine and viscous Lidocaine groups in terms of the relief of symptoms at each of the assessment times. There were no adverse outcomes in either group.
我们假设在这种制剂中，苯佐卡因（Hurricaine）的起效速度和效果与粘性利多卡因一样快且有效。这是一项前瞻性随机单盲比较研究，比较苯佐卡因和利多卡因作为胃肠道（GI）鸡尾酒中的局部麻醉剂的效果。当急诊医生开出GI鸡尾酒医嘱时，邀请18岁及以上的患者参与。除了30 cc的氢氧化铝镁和10 cc的唐那德外，患者被随机分配到等量的苯佐卡因或粘性利多卡因。在0、5、15和30分钟的时间间隔使用视觉模拟疼痛量表进行评估。共招募了82名患者（44名使用苯佐卡因，38名使用粘性利多卡因），每组的疼痛均有统计学上的显著改善（p < 0.001）。在每个评估时间点，苯佐卡因组和粘性利多卡因组在症状缓解方面没有统计学差异。两组均未出现不良结果。
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