来自不丹药用植物金黄乌头的刺乌头碱型二萜生物碱。

Hetisine-type diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum.

作者信息

Wangchuk Phurpa, Bremner John B, Samosorn Siritron

机构信息

Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.

出版信息

J Nat Prod. 2007 Nov;70(11):1808-11. doi: 10.1021/np070266k. Epub 2007 Oct 30.

DOI:10.1021/np070266k

PMID:17966986

Abstract

Investigation of Aconitum orochryseum, a Bhutanese traditional medicine ("gSo-ba Rig-pa") plant locally known as "Bong-kar", resulted in the isolation of three new hetisine-type diterpenoid alkaloids, named orochrine (1), 2-O-acetylorochrine (2), and 2-O-acetyl-7alpha-hydroxyorochrine (3), together with the previously reported alkaloids atisinium chloride (4) and virescenine (5). The structures of the new alkaloids were elucidated by spectroscopic data analysis.

摘要

对不丹传统医学（“藏医”）中一种当地名为“Bong-kar”的植物黄花乌头进行研究，结果分离出三种新的atisine型二萜生物碱，分别命名为黄花乌头碱（1）、2-O-乙酰基黄花乌头碱（2）和2-O-乙酰基-7α-羟基黄花乌头碱（3），以及先前报道的生物碱氯化阿替生（4）和绿翠雀碱（5）。通过光谱数据分析阐明了新生物碱的结构。