白藜芦醇抑制肿瘤坏死因子-α诱导的3T3-L1脂肪细胞中脂肪因子的变化。
Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes.
作者信息
Ahn Jiyun, Lee Hyunjung, Kim Suna, Ha Taeyoul
机构信息
Food Function Research Group, Korea Food Research Institute, 516, Baekhyun-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
出版信息
Biochem Biophys Res Commun. 2007 Dec 28;364(4):972-7. doi: 10.1016/j.bbrc.2007.10.109. Epub 2007 Oct 29.
Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-alpha are implicated in the induction of atherogenic adipokines, such as plasminogen activator inhibitor -1 (PAI-1) and IL-6, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of resveratrol on TNF-alpha-induced atherogenic changes of the adipokines in 3T3-L1 cells. Exposure to TNF-alpha for 24 h increased PAI-1 and IL-6 secretion and decreased adiponectin secretion. The mRNA expression of adipokines changed in parallel with mRNA expression. Resveratrol effectively reversed the secretion and mRNA expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. Decreased secretion levels and mRNA expression of adiponectin by TNF-alpha were also recovered by resveratrol treatment. Our results suggest that resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines.
肿瘤坏死因子-α（TNF-α）在肥胖啮齿动物和人类的脂肪组织中持续升高。TNF-α水平升高与促动脉粥样硬化脂肪因子的诱导有关，如纤溶酶原激活物抑制剂-1（PAI-1）和白细胞介素-6（IL-6），并与抗动脉粥样硬化脂肪因子脂联素的抑制有关。在本研究中，我们研究了白藜芦醇对TNF-α诱导的3T3-L1细胞脂肪因子动脉粥样硬化变化的影响。暴露于TNF-α 24小时会增加PAI-1和IL-6的分泌，并降低脂联素的分泌。脂肪因子的mRNA表达与mRNA表达平行变化。白藜芦醇有效地逆转了TNF-α诱导的促动脉粥样硬化脂肪因子PAI-1和IL-6的分泌和mRNA表达。白藜芦醇处理也恢复了TNF-α导致的脂联素分泌水平和mRNA表达的降低。我们的结果表明，白藜芦醇可能通过减弱TNF-α诱导的脂肪因子变化来改善肥胖诱导的心血管疾病，特别是动脉粥样硬化。
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