Krnjević K, Puil E, Werman R
Can J Physiol Pharmacol. 1976 Apr;54(2):172-6. doi: 10.1139/y76-029.
The most consistent effects produced by intracellular injections of guanosine 3',5'-cyclic monophosphate (cGMP) (but not 5'-guanosine 5'-monophosphate in spinal motoneurons of cats are a rise in membrane conductance, acceleration in time course of spike potentials, and accentuation of the post-spike hyperpolarization. Associated changes in resting potential are smaller, less constant, and more often in the depolarizing than hyperpolarizing direction, cGMP tends to increase electrical excitability but reduces excitatory post-synaptic potential amplitudes. Most of the effects of intracellular cGMP are quite different from, or indeed opposite to, those of either extra- or intracellular applications of acetylcholine and therefore not consistent with the proposal that cGMP is the internal mediator of muscarinic actions.
在猫的脊髓运动神经元中，细胞内注射3',5'-环磷酸鸟苷（cGMP）（而非5'-鸟苷单磷酸）产生的最一致的效应是膜电导增加、动作电位时程加速以及峰后超极化增强。静息电位的相关变化较小，不太稳定，且更多地是去极化而非超极化方向，cGMP倾向于增加电兴奋性，但会降低兴奋性突触后电位幅度。细胞内cGMP的大多数效应与细胞外或细胞内应用乙酰胆碱的效应截然不同，甚至相反，因此与cGMP是毒蕈碱作用的内源性介质这一观点不一致。
