McIntyre Dominick J O, Charlton Rebecca A, Markus Hugh S, Howe Franklyn A
Basic Medical Sciences, St. George's University of London, London, UK.
J Magn Reson Imaging. 2007 Dec;26(6):1596-606. doi: 10.1002/jmri.21198.
To investigate the relationship between subject age and white matter brain metabolite concentrations and R(2) relaxation rates in a cross-sectional study of human brain.
Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects. A major aim was to identify which parameters were most sensitive to changes with age. Spectra were analyzed using the LCModel method.
The apparent R2 of NAA and the LCModel concentration of Cr at short echo time were significantly correlated with age after multiplicity correction. Large lipid resonances were observed in the brain midline of some subjects, the incidence increasing significantly with age. We believe this to result from lipid deposits in the falx cerebri.
Since only short-echo spectroscopy showed a robust relationship between Cr and subject age, and detects more metabolites than long echo time, we conclude that short-echo is superior to long-echo for future aging studies. Future studies could usefully determine whether the Cr-age relationship is due to changes in concentration, T1, or both.
在一项关于人脑的横断面研究中，调查受试者年龄与脑白质代谢物浓度及R(2)弛豫率之间的关系。
采用长回波和短回波质子波谱成像技术，研究106名年龄在50至90岁之间的健康志愿者半卵圆中心白质中N-乙酰天门冬氨酸（NAA）+ N-乙酰天门冬氨酰谷氨酸（NAAG）、胆碱（Cho）、肌酸（Cr）和肌醇（mI）的浓度及R2弛豫率；从79名受试者获得了可用数据。一个主要目的是确定哪些参数对年龄变化最敏感。使用LCModel方法分析波谱。
在进行多重校正后，短回波时间下NAA的表观R2和Cr的LCModel浓度与年龄显著相关。在一些受试者的脑中线观察到较大的脂质共振信号，其发生率随年龄显著增加。我们认为这是由于大脑镰中的脂质沉积所致。
由于只有短回波波谱显示出Cr与受试者年龄之间存在稳健的关系，并且比长回波时间能检测到更多的代谢物，我们得出结论，对于未来的衰老研究，短回波优于长回波。未来的研究可以有效地确定Cr与年龄的关系是由于浓度变化、T1变化还是两者兼而有之。
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