水貂促肾上腺皮质激素原（POMC）编码cDNA的核苷酸序列及其与其他动物物种和人类垂体中POMC mRNA一级结构的比较分析。
Nucleotide sequence of cDNA coding for mink proopiomelanocortin (POMC) and its comparative analysis with POMC mRNA primary structures from pituitaries of other animal species and man.
作者信息
Mertvetsov N P, Karginov V A, Bondar A A, Morozov I V, Zelenin S M, Blinov V M
机构信息
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences.
出版信息
Biomed Biochim Acta. 1991;50(9):1057-64.
cDNA for proopiomelanocortin (POMC) of mink has been cloned and sequenced. A comparative analysis of the primary structures of mRNAs coding for proopiomelanocortins of eight animal species and man has been performed. The analysis has revealed conserved and variable POMC mRNA regions. High variability of some of the regions is suggested to be due to the peculiarities of their structural organization. A putative mechanism responsible for the mutations in variable regions is proposed. A tree of the evolutionary relations of POMC has been developed.
水貂促肾上腺皮质激素原（POMC）的互补脱氧核糖核酸（cDNA）已被克隆并测序。对编码八个动物物种和人类促肾上腺皮质激素原的信使核糖核酸（mRNA）的一级结构进行了比较分析。该分析揭示了促肾上腺皮质激素原信使核糖核酸的保守区和可变区。某些区域的高变异性被认为是由于其结构组织的特殊性所致。提出了一个负责可变区突变的假定机制。构建了促肾上腺皮质激素原的进化关系树。
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