Pacsa A S, Kummerländer L, Pejtsik B, Krommer K, Pali K
Cancer Res. 1976 Jul;36(7 PT 1):2130-2.
By the indirect immunofluorescence technique the presence of herpes simplex virus-specific antigens was investigated in cervical cells of 530 women with normal cervical epithelium, 175 with bland disorders, 52 with dysplasias, and 38 with invasive cervical carcinomas of the uterine cervix. Antigens were present in 9% of samples from women with normal cervical epithelium; they were present in 41% of the samples from women with bland disorders, 61% of those from dysplasia patients, and 94% of those from invasive carcinoma patients. The testing of 3 consecutive imprints of 68 antigen-positive and 232 antigen-negative women at 6-month intervals revealed that, in cervical cells, herpesvirus-specific antigens persisted throughout the 1-year period of the follow-up.
采用间接免疫荧光技术，对530名宫颈上皮正常的女性、175名有良性病变的女性、52名有发育异常的女性以及38名有宫颈浸润癌的女性的宫颈细胞进行了单纯疱疹病毒特异性抗原检测。在宫颈上皮正常的女性样本中，9%存在抗原；在有良性病变的女性样本中，41%存在抗原；在发育异常患者的样本中，61%存在抗原；在浸润癌患者的样本中，94%存在抗原。对68名抗原阳性和232名抗原阴性女性的连续3次印迹进行为期6个月的间隔检测，结果显示，在宫颈细胞中，疱疹病毒特异性抗原在长达1年的随访期内持续存在。
