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S100蛋白家族成员在膀胱肿瘤发病机制中的表达

Expression of S100 protein family members in the pathogenesis of bladder tumors.

作者信息

Yao Ruisheng, Lopez-Beltran Antonio, Maclennan Gregory T, Montironi Rodolfo, Eble John N, Cheng Liang

机构信息

Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Anticancer Res. 2007 Sep-Oct;27(5A):3051-8.

PMID:17970044
Abstract

The S100 proteins act as multifactional signaling factors that are involved in the regulation of diverse cellular processes. To explore the involvement of S100 genes in bladder cancers, S100 gene expressions were systematically evaluated at the RNA level by microarray and real-time PCR. Total RNAs were obtained from 4-hydroxybutyl(butyl)nitrosamine (OH-BBN)-induced mouse and rat bladder cancers, human bladder cancers and matched normal bladder urothelium. Microarray analysis was performed on mouse and rat bladder cancers; real-time PCR was performed in mouse, rat and human bladder cancers and their matched normal urothelium for confirmation. Microarray analysis revealed that 9 and 6 members of the S100 gene family were differentially expressed in mouse and rat bladder cancers, respectively. Thirteen members of the S100 gene family were confirmed by real-time PCR to be differentially expressed in human bladder cancers, with overexpression of S100A2, S100A3, S100A5, S100A7, S100A8, S100A9, S100A14, S100A15, S100A16 and S100P, and underexpression of S100A1, S100A4 and S100B. S100A1, S10OA3, S100A8, S10A9, S100A14, S100A15 and S100A16 showed similar patterns of differential expression in bladder cancers from mouse, rat and human. To our knowledge this is the first report of systematic evaluation of S100 gene expressions in bladder cancers. Our results indicate that differential expression of S100 gene family members is characteristic of bladder cancers and these genes may play important roles in bladder tumorigenesis and progression.

摘要

S100蛋白作为多效性信号因子,参与多种细胞过程的调控。为探究S100基因与膀胱癌的关系,我们通过微阵列芯片和实时定量PCR技术,在RNA水平上系统评估了S100基因的表达情况。总RNA取自4-羟基丁基(丁基)亚硝胺(OH-BBN)诱导的小鼠和大鼠膀胱癌、人膀胱癌组织及其配对的正常膀胱尿路上皮组织。对小鼠和大鼠膀胱癌组织进行微阵列芯片分析;对小鼠、大鼠和人膀胱癌组织及其配对的正常尿路上皮组织进行实时定量PCR以作验证。微阵列芯片分析显示,S100基因家族分别有9个和6个成员在小鼠和大鼠膀胱癌组织中差异表达。实时定量PCR证实,S100基因家族有13个成员在人膀胱癌组织中差异表达,其中S100A2、S100A3、S100A5、S100A7、S100A8、S100A9、S100A14、S100A15、S100A16和S100P表达上调,S100A1、S100A4和S100B表达下调。S100A1、S10OA3、S100A8、S10A9、S100A14、S100A15和S100A16在小鼠、大鼠和人膀胱癌组织中的差异表达模式相似。据我们所知,这是首次对膀胱癌组织中S100基因表达进行系统评估的报道。我们的结果表明,S100基因家族成员的差异表达是膀胱癌的特征之一,这些基因可能在膀胱肿瘤的发生和发展中发挥重要作用。

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