无溶剂条件下硫酸化氧化锆催化合成3,4-二氢嘧啶-2(1H)-酮（DHPMs）：竞争性多组分Biginelli反应与Hantzsch反应
Sulfated zirconia-catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) under solventless conditions: competitive multicomponent Biginelli vs. Hantzsch reactions.
作者信息
Angeles-Beltrán Deyanira, Lomas-Romero Leticia, Lara-Corona Victor H, González-Zamora Eduardo, Negrón-Silva Guillermo
机构信息
Departamento de Ciencias Básicas, UAM, Av. San Pablo No 180. C. P. 02200, México.
出版信息
Molecules. 2006 Oct 2;11(10):731-8. doi: 10.3390/11100731.
Abstract
The catalytic ability of ZrO(2)/SO(4)(2-) to promote solventless three-component condensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethyl acetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the same reactants but different temperature conditions. The sulfated zirconia catalyst can be recovered and recycled in subsequent reactions with a gradual decrease of activity.
摘要
研究了ZrO(2)/SO(4)(2-)促进多种芳香醛、尿素或硫脲与乙酰乙酸乙酯进行无溶剂三组分缩合反应的催化能力。在固体酸催化剂存在下，使用相同反应物但不同温度条件可得到由汉茨希和/或贝纳利多组分反应生成的产物。硫酸化氧化锆催化剂可回收并在后续反应中循环使用，但其活性会逐渐降低。
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