Curto M, McClatchey A I
Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
Br J Cancer. 2008 Jan 29;98(2):256-62. doi: 10.1038/sj.bjc.6604002. Epub 2007 Oct 30.
This review explores possible mechanisms by which the neurofibromatosis type-2 tumour suppressor Merlin regulates contact-dependent inhibition of proliferation. Starting from an evolutionary perspective, the concurrent emergence of intercellular contacts and proliferation control in multicellular organisms is first considered. Following a brief survey of the molecular and subcellular milieus in which merlin performs its function, the importance of different cellular and biological contexts in defining the function of merlin is discussed. Finally, an integrated model for merlin and the Ezrin, Radixin, and Moesin (ERM) proteins functioning in the regulation of cellular interfaces is proposed.
本综述探讨了2型神经纤维瘤病肿瘤抑制因子Merlin调节接触依赖性增殖抑制的可能机制。从进化的角度出发，首先考虑多细胞生物中细胞间接触和增殖控制的同时出现。在简要概述Merlin发挥功能的分子和亚细胞环境后，讨论了不同细胞和生物学背景在定义Merlin功能中的重要性。最后，提出了一个Merlin与埃兹蛋白、根蛋白和膜突蛋白（ERM）在调节细胞界面中发挥作用的整合模型。
