Fiévet Bruno, Louvard Daniel, Arpin Monique
UMR 144 CNRS-Institut Curie 26 rue d'Ulm, 75248 PARIS cedex 05, France.
Biochim Biophys Acta. 2007 May;1773(5):653-60. doi: 10.1016/j.bbamcr.2006.06.013. Epub 2006 Jul 10.
ERM (Ezrin, Radixin, Moesin) proteins are membrane-cytoskeleton linkers that regulate the structure and the function of specific domains of the plasma membrane. ERM proteins are expressed in all metazoan analyzed so far. Genetic analysis of ERM protein functions has recently been performed simultaneously in three different organisms, mouse, Drosophila melanogaster and C. elegans. These studies have revealed a remarkable conservation of the protein functions through evolution. Moreover they have shed light on the crucial role these proteins play in various physiological processes that occur in epithelial cells.
ERM（埃兹蛋白、根蛋白、膜突蛋白）家族蛋白是细胞膜与细胞骨架的连接蛋白，可调节质膜特定区域的结构和功能。到目前为止，已在所有分析过的后生动物中发现了ERM蛋白的表达。最近，已同时在三种不同的生物体——小鼠、黑腹果蝇和秀丽隐杆线虫中对ERM蛋白的功能进行了遗传学分析。这些研究揭示了这些蛋白在进化过程中的显著功能保守性。此外，这些研究还揭示了这些蛋白在发生于上皮细胞中的各种生理过程中所起的关键作用。
