Gamper Nikita, Shapiro Mark S
Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Nat Rev Neurosci. 2007 Dec;8(12):921-34. doi: 10.1038/nrn2257.
Over the past decade, there has been an explosion in the number of membrane transport proteins that have been shown to be sensitive to the abundance of phosphoinositides in the plasma membrane. These proteins include voltage-gated potassium and calcium channels, ion channels that mediate sensory and nociceptive responses, epithelial transport proteins and ionic exchangers. Each of the regulatory lipids is also under multifaceted regulatory control. Phosphoinositide modulation of membrane proteins in neurons often has a dramatic effect on neuronal excitability and synaptic transmitter release. The repertoire of lipid signalling mechanisms that regulate membrane proteins is intriguingly complex and provides a rich array of topics for neuroscience research.
在过去十年中，已显示对质膜中磷酸肌醇丰度敏感的膜转运蛋白数量激增。这些蛋白质包括电压门控钾通道和钙通道、介导感觉和伤害性反应的离子通道、上皮转运蛋白和离子交换器。每种调节性脂质也受到多方面的调节控制。神经元中膜蛋白的磷酸肌醇调节通常对神经元兴奋性和突触递质释放有显著影响。调节膜蛋白的脂质信号传导机制非常复杂，为神经科学研究提供了丰富的课题。
